Formulation and Evaluation of Antibacterial Novel Herbal Hand Sanitizer gel containing Aloe Barbadensis Extract

The main of the research work was to develop and characterize of Novel Herbal Hand Sanitizer gel Containing Aloe barbadensis extract for the effectiveness of the gel against bacteria on the palms of the hands. Isopropyl alcohol based novel hand sanitizer has gained more attention over the last several decades due to its reputable medicinal properties and from different pharmaceutical, health care product has been manufactured.

Herbal hand sanitizer gel was prepared and characterized with respect pH, viscosity, spreadability, phytochemical screening, In vitro drug release and physical stability. The anti-microbial activity of the formulated herbal hand sanitizer gel was tested against Escherichia coli, Staphylococcus aureus Candida albicans and Pseudomonas aeruginosa by agar pour techniques and Radical Scavenging Activity by the DPPH Assay.

The gel base was optimized by preparing hand sanitizer formulations containing Carbomer and triethanolamine at ratios of 0.25%:0.5%, 0.5%:1%, and 0.5%:2% and mixed with aloe vera leaf extract sanitizer liquid. The herbal hand sanitizer gel was showed pH, viscosity, Spreadability was found 6.2, 50.02(cps), and 9.5 ±0.12g.cm/sec, respectively. The physical stability of hand gels containing aloe vera extract was measured at storing at room temperature and accelerated temperature and humidity (25±20C, 60±5% RH) and (40±20C, 75±5% RH) for up to six months.

The effectiveness of the gels was examined on the palms of 30 respondents. Moreover, significantly the study existent that herbal hand sanitizer gel of aloe vera can be promised to be effective enough and enhanced safe potential for the retention of palms of hands.