Synthesis, Develop and Characterization of New Quinoline-Sulfonamides derivatives as Specific Tumer-Related CARBONIC ANHYDRASE Isoform XII Inhibitors

Numerous studies highlight the significant responsibility of CARBONIC ANHYDRASE Isoform XII in the mechanisms underlying the onset and progression of cancer. Our research focuses on the synthesis of Quinoline-Sulfonamides, which are compounds designed to inhibit this enzyme, a key player in cancer development. Using Molegro Virtual Docker (MVD), we conducted molecular modeling of these compounds, targeting Carbonic Anhydrase Isoform XII, and calculated their binding energies to identify the most promising candidate. Among the compounds studied, compound 1..e exhibited the highest binding energy at -166.694kcal/mol in comparison to 4-propylthiobenzen sulfonamide (VD9), Which has a binding energy of -115kcal/mol , Several of these compounds were synthesized efficiently using an economical and environmentally friendly aqueous method with high yield ranging between 70 to 86%.Their physicochemical properties were studied using Marvin Sketch and structural identification were confirmed through different analytical methods, involving Mass Spectrography, Infrared Spectrography, and nuclear magnetic resonance.