Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2026
  • Volume: 19
  • Issue: 5

Determinants of Rutin, Myricetin, Quercetin and Kaempferol Compounds in Ethanol Extracts of Sauropus androgynus, Moringa oleifera Lam and Coleus amboinicus Lour: To Sustain Exclusive Breastfeeding

  • Author:
  • Sukmayati Alegantina1,*, Efriwati Efriwati2,**, Ani Isnawati3,***, Nanang Yunarto4, Ariyani Noviantari5, Maratu Soleha6, Lucie Widowati7, Dian Sundari8, Suharmiati Suharmiati9, Ifa Manzila10, Putri Reno Intan11
  • Total Page Count: 7
  • Page Number: 2052 to 2058

1Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

10Research Center for Horticultural and Estate Crops, Research Organization for Agriculture and Food, National Research and Innovation Agency, Bogor, Indonesia

11Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

2Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

3Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

4STIKES Widya Dharma Husada, Tangerang, Indonesia

5Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

6Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

7Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

8Research Center for Public Health and Nutrition, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

9Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency, Bogor, Indonesia

12Animal Biomedical Study Program, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

*Corresponding Author E-mail: sukm004@brin.go.id

**efri003@brin.go.id

***anii001@brin.go.id

Abstract

This study aimed to determine the levels of rutin, quercetin, myricetin, and kaempferol in the ethanol extracts of Sauropus androgynus, Moringa oleifera Lam, and Coleus amboinicus Lour leaves, and to evaluate their potential as galactagogue agents to enhance breast milk production in support of sustainable exclusive breastfeeding practices. Extraction of each plant was carried out using percolation method with 70% ethanol as solvent, and analysis of the galactagogue compounds was performed using High-Performance Liquid Chromatography (HPLC). The results showed that the ethanol extracts of S. androgynus, M. oleifera Lam, and C. amboinicus Lour leaves contained rutin, quercetin, myricetin, and kaempferol, with myricetin being the most abundant compound among the three extracts. The consumption of rutin, quercetin, myricetin, and kaempferol in the ethanol extracts of S. androgynus, M. oleifera Lam, and C. amboinicus Lour leaves may help increase breast milk production and support the continuation of breastfeeding and exclusive breastfeeding. Therefore, the ethanol extracts of S. androgynus, M. oleifera Lam, and C. amboinicus Lour leaves have potential to be formulated as nutritional sources for pregnant and breastfeeding women to maintain and enhance the sustainability of breastfeeding and exclusive breastfeeding practices. However, further research is required to confirm safety and efficacy of these ethanol extracts.

Keywords

Galactagogue, HPLC, S. androgynus, M. oleifera Lam, C. amboinicus Lour