Formulation and Evaluation of Anti-acne Nanogel from Bambusa Vulgaris

The medicinal plant, Bambusa vulgaris, has been identified with several phytochemicals which may act against acne. Now, with a heavy focus on improving therapeutic efficacy, especially for wound healing and acne, the plant’s drug delivery systems embedded in nanotechnological approaches are growing in popularity. Hence the present work aims to formulate an anti-acne nanogel employing the leaf extract of Bambusa vulgaris with the polymer Carbopol 934 in a gel matrix. The antibacterial activity of the developed gel was tested on Escherichia coli and Staphylococcus aureus, using the cup plate and Franz diffusion techniques. The results showed that the developed herbal nanogels demonstrated satisfactory physicochemical characteristics, with optimal viscosity (4533-4787 cp), pH (6.23-6.36), and spreadability (30-43mm). The no toxicity of this nanogel can be attributed to its inhibition of bacterial growth due to the formation of significant zones of inhibition comparable to that by standard antibiotics. Moreover, the stability of this formulation demonstrates its promise for being a safe and effective remedy for acne, especially in respect of inhibiting bacterial proliferation. Bambusa vulgaris-based herbal nanogels could thus represent a natural option with high antimicrobial activity and a possible alternative for improving acne treatment options.