Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2026
  • Volume: 19
  • Issue: 5

Correlation between Serum Vascular Endothelial Growth Factor A and Neurological Markers in Hypothyroidism: Implications for Neuroprotection and Prognostic Assessment

  • Author:
  • Induja Viswanathan1, Vickneshwaran Vinayagam1,*, Siva Ranganathan Green2, TMJ Santhoshakumari1, Sumathi Saravanakumar1, Muraliswaran Perumal1,3
  • Total Page Count: 6
  • Page Number: 1995 to 2000

1Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be university), Puducherry, India

2Department of Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be university), Puducherry, India

3JR Medical College and Hospital, Bharath Institute of Higher Education and Research (To be Deemed University), Tamilnadu, India

*Corresponding Author E-mail: vickneshwaranvinayagam@mgmcri.ac.in

Abstract

Hypothyroidism, a state of underactive thyroid, can lead to neurological manifestations. Hashimoto’s disease, an autoimmune disorder, is a common cause of hypothyroidism. Vascular endothelial growth factor A (VEGF A) is essential for the formation of new blood vessels and tissue repair after brain injury. This study aims to assess and correlate the serum levels of VEGF A with brain injury markers such as neuron-specific enolase (NSE) and s100b in hypothyroidism.

A cross-sectional study was conducted on 131 subjects, comprising 68 patients with hypothyroidism and 63 age- and sex-matched control subjects. Serum levels of VEGF A, NSE, and s100b were estimated using commercially available ELISA kits. The thyroid profiles, including free T3(fT3), free T4(fT4), and thyroid-stimulating hormone (TSH), were assessed using chemiluminescence assays.

The study found a significant decrease in serum VEGF A, NSE, and s100b levels in hypothyroid subjects compared to control subjects. A positive correlation was observed between serum VEGF A levels with NSE and s100b marker levels. Receiver operating characteristic (ROC) analysis revealed that serum VEGF A had the best diagnostic accuracy in predicting brain injury in hypothyroidism.

The study suggests that assessment of NSE and s100b along with thyroid profile may be used as a prognostic marker in preventing the onset of neurological manifestations in hypothyroidism. The correlation between VEGF A and brain injury markers highlights the potential role of VEGF A in neuroprotective events.

Keywords

Hypothyroidism, Vascular endothelial growth factor, Neuron specific enolase, Calcium Binding Protein beta, Brain injury marker