1Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
2Deptt. of Biosciences, Barkatullah University, Bhopal (MP), India
3Columbia Institute of Pharmacy, Raipur
*Corresponding Author: Nirmala Gupta, Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), India
Online published on 21 February, 2013.
The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104 μg/100 μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p <0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice
Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin carcinogenesis, Glutathione
