A Review on Self-Micro Emulsifying Drug Delivery System

Self-microemulsifying drug delivery systems (SMEDDS), which can be a promising method for improving the bioavailability of poorly water-soluble drugs, have attracted considerable attention recently. This review highlights the important aspects of SMEDDS such as formulation components, process of preparation, and mode of action. One of the physicochemical properties being studied in the current study is the effect of choice of surfactant and co-surfactant on the size of droplets and their stability. Some advancements in the techniques used for characterization and in vivo studies that show the efficiency of SMEDDS in increasing therapeutic outcomes have been presented in this study. Future research directions in the area are mentioned, together with the problems associated with the regulations and production at scale level. The aim of the current review is to provide an extensive understanding of SMEDDS to scientists and academics.