Development and Characterization of Brucine-Loaded Self-Nanoemulsifying Drug Delivery System

Brucine, a pharmacologically active alkaloid, is restricted in its clinical utility because of its inadequate water solubility as well as low oral bioavailability. To address these limitations, a Self-Nanoemulsifying Drug Delivery System (SNEDDS) incorporating Brucine had been formulated and thoroughly evaluated. The formulation process involved optimizing a blend of co-surfactant, oil and surfactant components to maximize drug solubilization and absorption through gastrointestinal tract. Resulting nano emulsion demonstrated nanoscale droplet size, strong encapsulation efficiency, and notable formulation stability. In vitro studies presented a marked enhancement of the rate of disintegration of Brucine compared to its unformulated counterpart, while in vivo pharmacokinetic assessments revealed significantly enhanced oral bioavailability. Overall, these results support the possibility of SNEDDS as an effective delivery platform to improve Brucine’s therapeutic performance and pave the way for its possible clinical application.