Enhancing Transdermal Drug Delivery: Utilizing marine derived chitosan for Advanced Therapeutic Applications

Recently, chitosan has attracted a lot of attention to both pharmaceutical and food industry due to its diverse properties. The second natural polymer that is abundant and biodegradable and biocompatible is chitin the precursor of chitosan which is commonly found in the exoskeletons of the marine organisms like fishes, crab, snail and other species. The transdermal drug delivery system is a promising method of drugs administration via the skin and it is safe, effective and patient compliant. Use of chitosan to prepare transdermal patches can be an effective aspect to consider in drug delivery system in future.

The present aim of study was to extract chitosan from Pomacea canaliculata and prepare chitosan based transdermal patch.

The Pomacea canaliculata was selected for extraction of chitosan. The process for extraction of chitosan: deproteination involves the removal of protein from the raw material; demineralization aimed for removing inorganic minerals especially calcium carbonate from the raw material to get chitin and deacetylation involves the removal of acetyl groups from chitin to obtained chitosan, a soluble and bioactive derivate.

The formulations prepared for chitosan based transdermal patches where chitosan was extracted from Pomacea canaliculata. The results are based on the quantity used in the formulations.

In this study, chitosan based transdermal patches provide safety, efficacy and improve patient compliance. They provide sustainability in the manufacturing process leads to green manufacturing. Transdermal patches showcase the potential for sustainable, cost-effective and patient friendly drug delivery systems.