Overview of Transdermal Delivery System

Two well-known prolonged-release dose forms are transdermal patches and medicated plasters (patches). These days, many reports of in vivo “adhesion lacking” are still sent to regulatory bodies, despite the fact that adequate adhesion to the skin is strictly correlated with the effectiveness and safety of the therapeutic therapy. The ability of a patch to form a bond with the surface of another material under light pressure and brief contact (tack); the adhesive’s resistance to flow (shear adhesion); and the force needed to remove a patch from a surface (peel adhesion) should all be taken into account when describing the adhesive properties of a patch. Topics covered: This manuscript describes the quality control of patches and the most used techniques for measuring adhesive characteristics throughout development research. Additionally covered is the impact of formative variables on patch adhesive characteristics and their potential correlation with in vivo adhesion performances. Expert opinion: Regulatory bodies should provide appropriate recommendations to assess these qualities throughout development, and pharmacopoeias should take into account the possibility of implementing compendia testing to assay the quality of adhesive patch properties.