Recent Advances in Analytical Techniques for Itraconazole - Brief Review

Itraconazole is an oral triazole antifungal medication used to treat superficial and systemic fungal infections in the mouth, throat, lungs, and nails. Certain brands may not be appropriate for treating nail infections. It may be prepared for topical and systemic use and is well-known for its antimycotic qualities. The goal of this review is to gather the national and international literature on itraconazole estimation in pharmaceutical formulations and bulk, with a focus on UV spectrophotometric and high performance liquid chromatography (HPLC) techniques, High performance thin layer chromatography (HPTLC), Gas chromatography (GC), Gas chromatography-Mass spectroscopy (GC-MS) and Liquid chromatography Mass Spectroscopy (LC-MS). For UV spectroscopy, the important parameters analyzed are λmax and solvent, and for HPLC and HPTLC, the stationary phase, mobile phase, retention period, and column specifications. Validation of an analytical method is a requirement to demonstrate that the method is suitable and appropriate for the intended use, often a prerequisite for analytical purposes. This paper reviews different analytical methods for the determination of itraconazole and its combinations in pharmaceutical drug. It also involves the validation of itraconazole and development of various analytical methods used for different dosage forms.