Synthesis of 2-(substituted phenyl)-3-[4-1-thioanisole] -1,3-thiazol-2-yl}amino]-5-methyl1, 3-thiazolidin-4-ones as antihyperglycemic agents

Compounds were prepared by the bromination of 4-Acetyl Thio anisole in chloroform followed by condensation with substituted benzaldehyde thiosemicarbazones in ethanol to get 4-(1-Thio Anisoyl)-2-(Substituted benzylidine amino)-1,3-thiazoles. These compounds on cyclisation yield Thiazolidin-4-ones by reacting with thiolactic acid in dioxane using pinch of ZnCl₂ as catalyst. Synthesised compounds were characterised by chemical analysis, IR, NMR and mass spectra. Purity of the compounds were checked by TLC. These compounds were subjected to antihyperglycemic study in normal rats in sucrose loaded model (SLM) and found them active also study the evaluation of blood sugar by alloxan model.