1Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia, 55281
*Email: alfin.harjuno.d@mail.ugm.ac.id (corresponding author):
Online published on 13 March, 2026.
Dengue fever (DF) remains a major public health issue in Indonesia, with an incidence of 77.96/ 100,000 people. Aedes aegypti and Aedes albopictus serve as primary vectors, yet rising insecticide resistance complicates control efforts. This review examines resistance mechanisms in Aedes sp. mosquitos, including target site mutations such as knockdown resistance (kdr) in voltage-gated sodium channels and acetylcholinesterase. Metabolic resistance, driven by detoxifying enzyme overexpression (cytochrome P450s, glutathione S-transferases), is another concern. Emerging mechanisms, like gut microbiota alterations and epigenetic modifications, further challenge intervention strategies. Adaptive control strategie such as insecticide rotation, synergist application, genetic interventions, biological and environmental control methods are proposed to combat the emergence of Aedes sp. insecticide resistance in Indonesia.
Aedes aegypti, Aedes albopictus, Dengue vector control, Genetic mutation, Insecticide resistance, Metabolic resistance, Kdr mutation, VGSC mutation, Cytochrome P450, GST mutation, Metabolic resistance, Behavioral resistance
