1Veer Madho Singh Bhandari Uttarakhand Technical University, Dehradun-248 001, Uttarakhand, India
*Corresponding Author: Shivani Kala, Veer Madho Singh Bhandari Uttarakhand Technical University, Dehradun-248 001, Uttarakhand, India, Email: shivani.kala88@gmail.com
Online Published on 01 July, 2025.
The aim of current investigation was to analyze synergistic effect of natural penetration enhancers in combination with a synthetic drug in an animal model to enhance transdermal drug delivery.
Initially, while carrying out the work in 2021-23 trial formulation batches were prepared with different penetration enhancers and then these were undergone through optimization study to optimize various parameters. A 32 full factorial design was utilized for study of optimization. An appropriate animal model was selected to analyze anti-inflammatory and analgesic effect of product. Statistical analysis was doneby utilizing one-way ANOVA, post hoc Tukey-Kramer test utilizing GraphPad Prism 9. Value of p<0.05 wasdeemed considerable.
It was concluded from the study that reduction in paw licking activity was approximately found to be 69.52, 72.32 and 74.10% with Emulgel 1, Emulgel 2 and Emulgel 3, compared with group of control (p<0.05 vs control). These findings showed that the analgesic effect of all three formulations was promising. Emulgel 3 i.e., Sapindus mukorossi showed better anti-inflammatory activity in comparison to Allium sativum and Zingiber officinale.
Analgesic, Anti-inflammatory, Natural penetration enhancer, Synergistic effect, Transdermal drug delivery
