1Department of Microbiology, Faculty, Kirşehir Ahi Evran University of Medicine, Kirşehir-Türkiye
10Department of Aesthetic, Private Clinic, Plastic and Reconstructive Surgery, Konya-Türkiye
2Department of Animal Health, Ağri Ibrahim Çeçen University, Eleşkirt Celal Oruç School of Animal Production, Ağri-Türkiye
3Department of Pathology, Faculty of Medicine, Çukurova University, Adana-Türkiye
4Department of Microbiology, Faculty of Medicine, Çukurova University, Adana-Türkiye
5Department of Nutrition and Dietetics, Ağri Ibrahim Çeçen University, High School of Health, Ağri-Türkiye
6Department of Biochemistry, Faculty of Science, Atatürk University, Erzurum-Türkiye
7Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum-Türkiye
8Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Çukurova University, Adana-Türkiye
9Department of Fisheries Technology, Çanakkale Onsekiz Mart University, Çanakkale Academy of Applied Sciences, Çanakkale-Türkiye
*Corresponding Author: Selvinaz Yakan, Department of Animal Health, Ağri Ibrahim Çeçen University, Eleşkirt Celal Oruç School of Animal Production, Ağri-Türkiye, Email: syakan@gmail.com, ORCIDs: 0000-0003-3140-2937, 0000-0002-6274-9012, 00000002-4951-8703, 0000-0002-5921-3559, 0000-0001-9585-3169, 0000-0001-5993-1668, 0000-0002-0042-890X, 0000-0002-10398556, 0000-0001-5791-7491, 0000-0002-9157-3407
Online Published on 01 July, 2025.
One of the most important complications of the wound is tissue infection. One of the most common causes of tissue infections is microorganisms such as Staphylococcus. This research investigates the impact of argan oil and polyhexanide on the healing process in wounds with tissue loss infected with Staphylococcus aureus (S. aureus).
The study involved 45 male mice, with 10 mm skin incisions made on their backs under general anaesthesia to create wounds. After 24 hours, an S. aureus (ATCC) suspension was applied to the scars. Wound cultures were collected from each mouse 48 hours later and this was repeated every 48 hours until cultures confirmed S. aureus infection. Treatment commenced once S. aureus growth was detected. The mice were randomly assigned to three groups: A control group (wound created, but no treatment applied), an argan group (1 mL of argan oil administered to the wound via syringe) and a polyhexanide group (1 mL of polyhexanide administered similarly). The wound diameters and clinical symptoms were monitored daily. On the 7th and 14th days, tissue samples were taken from the sacrificed mice for histopathological examination.
Based on clinical and histopathological observations, both argan oil and polyhexanide were found to be effective in treating S. aureus-infected wounds with tissue loss in mice. However, argan oil demonstrated a superior therapeutic potential compared to polyhexanide.
Argan, Mice, Polyhexanide, Staphylococcus aureus
