1Department of Plant and Animal Production, Food Agriculture and Livestock Vocational School, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye
2Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye
3Food Agriculture and Livestock Vocational School, Burdur Mehmet Akif Ersoy University, Laboratory and Veterinary Health Associate Degree Program, Burdur, Türkiye
4Department of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey
5Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye
6Experimental Animals Application and Research Center, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye
*Corresponding Author: R. Kiyici, Department of Plant and Animal Production, Food Agriculture and Livestock Vocational School, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye, Email: rkiyici@mehmetakif.edu.tr
Online Published on 14 October, 2024.
Sweetgum oil has been traditionally used to treat wounds, respiratory tract problems, osteoarthritis and various stomach ailments. In this study, the effects of sweetgum oil on ethanol-induced chronic gastritis in rats were investigated.
Thirty Wistar albino rats were divided into 5 groups. Group 1 served as control and received no treatment. Except for control, all animals received oral doses of 8 g/kg of 56% ethanol twice a week for 4 weeks to induce gastritis. Group 2, the ethanol group received only ethanol. Group 3 was treated with the conventional treatment of 20 mg/kg omeprazole daily for 2 weeks. Group 4 was treated with 150 mg/kg of sweetgum oil dissolved in olive oil daily for 2 weeks. Group 5 was treated orally with 0.6 ml olive oil daily for 2 weeks.
Histopathological and immunohistochemical examinations were performed on the stomach samples. Ethanol caused severe erosive ulcerative lesions in the gastric mucosa and inflammatory cell infiltrations in the propria mucosa. In immunohistochemical examination, marked increases in interleukin-10 (IL-10), interleukin-1β (IL-β) and platelet endothelial cell adhesion molecule 1 (PECAM-1) expressions were observed in this group. Omeprazole treatment significantly reduced these pathological findings. Sweetgum oil provided significant improvement in histopathological and immunohistochemical findings, but the protection was not as effective as omeprazole. Moderate healing effects were also observed with olive oil. Sweetgum oil has a curative effect on chronic gastritis, although it is not as effective as omeprazole. Moreover, olive oil has a curative effect on gastritis.
Chronic gastritis, Histopathology, Immunohistochemistry, Rat, Sweetgum oil, Traditional medicine
