1Department of Veterinary Biochemistry, College of Veterinary Science, Tirupati-517 502, Andhra Pradesh, India
2Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Tirupati-517 502, Andhra Pradesh, India
3Department of Veterinary Parasitology, College of Veterinary Science, Tirupati-517 502, Andhra Pradesh, India
4Livestock Research Station, Sri Venkateswara Veterinary University, Palamaner-517 408, Andhra Pradesh, India
*Corresponding Author: Shiny Joy, Department of Veterinary Biochemistry, Nagpur Veterinary College, Nagpur-440 006, Maharashtra, India, Email: shiny.joy@gmail.com
Online published on 13 February, 2023.
A study was conducted to evaluate the antioxidant and immunological profile of methanolic extract of Adhatoda vasica leaves (AVE) in naturally infected sheep with gastrointestinal nematodes and compared with commonly used anthelmintic albendazole in sheep.
Fifty four sheep found positive for gastrointestinal nematodes were divided into 3 equal groups, GI (infected-untreated: control), GII (infected- AVE treated) and GIII (infected- albendazole treated). Blood samples were drawn on 5th and 14th day after treatment for analysis of oxidative stress markers such as TBARS, TAC, SOD and catalase and immunological parameters such as total immunoglobulin, IgG and IL-10.
Helminthiasis in sheep cause a considerable oxidative stress. The anthelmintic activity of Adhatoda vasica surpassed the conventional synthetic drug albendazole in sheep in terms of oxidative and immunological changes in blood.
Adhatoda, Catalase, Helminthiasis, IL-10, Immunoglobulin, SOD, TAC, TBARS
