Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, Punjab, India
*Corresponding Author: D.K. Sharma, Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, Punjab, India, Email: dineshcovas79@gmail.com
Online Published on 09 May, 2022.
The antipyretic, analgesic and anti-inflammatory activities of two concentrations (100 and 200 mg/kg) of ethanolic extract of leaf, bark, flower and fruit pulp of C. fistula were determined in male wistar albino rats.
Antipyretic activity was assessed by E. coli endotoxin induced pyrexia. Analgesic activity was assessed by hot plate, tail immersion and acetic acid induced writhing test. Anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema assay.
Significant (p<0.05) antipyretic activity was exhibited from 2 h onwards by bark extract @ 200 mg/kg and from 3h onwards by bark extract @100 mg/kg and leaves extract @ 200 mg/kg as compared to control group. Significant (p<0.05) analgesic activity was shown by extract of bark @ 200 mg/kg as it is evident by increase in reflex time in hot plate (90,120,180 min), tail immersion test (120,180 min) and inhibition of writhing (32.12%). Significant (p<0.05) anti-inflammatory activity was exhibited from 3 h post administration by bark @ 200 and leaves @ 100 and 200 mg/kg.
Analgesic, Anti-inflammatory, Antipyretic, Cassia fistula
