Indian Journal of Animal Research
SCOPUSWeb of Science
  • Year: 2022
  • Volume: 56
  • Issue: 2

Immunological effects of propofol, ketamine and isoflurane in dexmedetomidine and butorphanol premedicated dogs

  • Author:
  • Hitesh Bayan, Kushal Konwar Sarma1, Parimal Roychoudhury2, Devajani Deka3
  • Total Page Count: 6
  • Page Number: 222 to 227

1Department of Veterinary Surgery and Radiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati-781 022, Assam, India

2Department of Veterinary Microbiology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I), Selesih, Aizawl-796 014, Mizoram, India

3Department of Veterinary Public Health and Epidemiology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I), Selesih, Aizawl-796 014, Mizoram, India

Department of Veterinary Surgery and Radiology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I), Selesih, Aizawl-796 014, Mizoram, India

*Corresponding Author: Hitesh Bayan, Department of Veterinary Surgery and Radiology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I), Selesih, Aizawl-796 014, Mizoram, India, Email: hbayan@gmail.com

Online Published on 30 March, 2022.

Abstract

The study was conducted to evaluate the immunological effects of Propofol, Ketamine and Isoflurane in Dexmedetomidine and Butorphanol premedicated dogs.

Four groups of dogs (A, B, C and D), 6 animals in each, were premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol. Induction was done with Propofol (A and B) and Ketamine (C and D). Anaesthesia was maintained with Isoflurane (A and C), Propofol (B) and Ketamine (D). The cytokine mRNA expressions and cell mediated immunity response were studied before and after anesthesia at different time intervals.

The down regulation of IL-2 was observed during the study period with significant changes in Group A, C and D except group B. The IL-4 and IL-10 showed non-significant up regulation in all the groups and gradually returned to the pre-induction level. The IL-6 showed significant down regulation at 2 hours and day 1 and up regulation on day 3 in all the groups. The TGF-p showed up regulation in all the groups and then came to the pre-induction level with significant changes in Group A, C and D.

Keywords

Anaesthesia, Cytokine, Dog, Immunity, NBT, Surgery