Division of Animal Genetics, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, Uttar Pradesh, India
*Corresponding author's e-mail: anuj_vet99@rediffmail.com
Online published on 7 May, 2018.
Toll-like Receptor 9 (TLR9) play an important role in recognition of components of intracellular pathogens like Mycobacterium bovis and subsequent activation of both innate and adaptive immune response and is potential strong candidates for investigating genetic basis of disease resistance. Present investigation was aimed at exploring the association of four SNPs in TLR9 gene with susceptibility/resistance against bovine tuberculosis infection in cattle. Three of SNPs under investigation (rs210982793, rs207807011, rs209190268) revealed polymorphism whereas monomorphism was observed in SNP rs55617140. SNP loci rs210982793 and rs207807011 were significantly (P < 0.01) associated with susceptibility to bovine tuberculosis in the case control population. Both these SNPs loci were non-synonymous, thus suggestive of their functional rolein theimmune response against bovine tuberculosis.
Bovine tuberculosis, Immune response, Resistance, SNP, Toll-like receptors
