Indian Journal of Animal Research
SCOPUSWeb of Science
  • Year: 2018
  • Volume: 52
  • Issue: 1

In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats

  • Author:
  • P. Gowrav Adiga, N.B. Shridhar, Jagadeesh S. Sanganal, Suguna Rao1, N. Shilpa, V. Aparna, I.M. Santhosh, M. Tirumala, B.M. Sindhu
  • Total Page Count: 4
  • Page Number: 144 to 147

1Department of Veterinary Pathology, Veterinary College(KVAFSU), Bidar-585401, Karnataka, India

Department of Veterinary Pharmacology and Toxicology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Hebbal, Bengaluru-560 024, Karnataka, India

*Corresponding author's e-mail: adiga.gowrav@gmail.com

Online published on 9 February, 2018.

Abstract

The present study was designed to evaluate anti-tumor activity of the methanolic extract of stem bark of Croton oblongifolius in Sprague Dawleyrats. Thetumor wasinduced inrats by DMBA given orallyand intramammarilyand challengingwith plant extract. After obtaining suitable mass of tumor, the extract was gavaged to rats @ 200, 500 and 800 mg/kg which showed reduction in mammary tumor volume in dose-dependent manner, which was supported by histopathological observations of the treatment groups.

Keywords

Anti-tumor activity, Croton oblongifolius, Histopathology