1Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China
2Shanxi Medical University Clinical Training Centre, Taiyuan, Shanxi, 030001, China
3Laboratory and Equipment Management Office, Tianjin University of Science & Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China
4Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China
Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science & Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China
*Corresponding author's e-mail: huarb@tust.edu.cn
Online published on 10 February, 2017.
Resveratrol (RSV) as a naturally occurring small molecule has been reported to benefit the cardiovascular system through a dietary supplementation. However, the relevant genetic regulation by RSV has been uncovered. This work is solely to investigate how RSV increases a fecal excretion of total sterols of HF fed C57BL/6J mice to block lipid accumulation in vivo through regulation of PPRAoc, HMG-CoA-R, CYP7A1, LDL-R and ABCG5 genes. The results showed that RSV significantly improved the excretion of total sterols through up regulation of mRNA expressions of PPARoc, CYP7A1, LDL-R, ABCG5 and down regulation of HMG-CoA-R. These data indicate that beneficial effects from RSV were associated with the favorably altered expression of hepatic and large intestine genes in HF fed mice.
Gene expression, HF diet, Mice, RSV
