1Department of Veterinary Clinical Medicine Ethics and Jurisprudence, Madras Veterinary College, Chennai-600 007, India
Department of Veterinary Biochemistry, Madras Veterinary College, Chennai-600 007, India
*Corresponding author'e-mail: pslsesh@yahoo.com and address: Deptt. of Veterinary Physiology & Biochemistry, Veterinary College & Research Institute, Ramayanpatti, Tirunelveli – 627 001
Online published on 12 August, 2015.
Dilated cardiomyopathy occurs more frequently in large breed of dogs and the common form is the Idiopathic Dilated Cardiomyopathy. Xanthine oxidase is considered as one of the potent enzyme causing oxidative stress in the failing heart, and it uncouples cardiac energy consumption from cardiac contraction resulting in heart failure. In the present study xanthine oxidase activity was estimated in the serum of Dilated cardiomyopathy affected dogs and compared with that of healthy dogs serving as control. Similarly, other known cardiac enzyme markers like creatine kinase, aspartate transaminase and lactate dehydrogenase activities were also estimated. The results showed a 300% increase in the specific activity of xanthine oxidase and a 200% increase in the total activity of xanthine oxidase. This ind icates that measurement of xanthine oxidase activity can serve as an early biochemical marker for diagnosis of Dilated cardiomyopathy in canines.
Cardiology, Cardiac markers, Dilated cardiomyopathy, Dogs, Xanthine oxidase
