Oxidative Stress Response During Surgery Under Ketamine/Propofol Anaesthesia in Acepromazine-Xylazine Premedicated Horses

The study was conducted in twelve clinical cases of horses undergoing diagnostic and surgical procedures warranting general anaesthesia. The cases were randomly divided into two groups: group I and group II each consisting of six cases. Xylazine @ 0.5mg/kg and Acepromazine @ 0.03 mg/kg body weight were used as pre-anaesthetic in both the groups. Ketamine @ 2.20 mg/kg body weight and 0.50mg/kg/min was used as induction and maintenance agent in group I and Propofol @ 2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance agent in group II. A non significant difference in the neutrophil, lymphocyte, eosinophil, and monocyte counts were observed in both the groups. The magnitude of blood glucose was higher in group I compared to that of group II. A non significant reduction in total serum protein was observed after sedation, after induction, during maintenance and after recovery in both the groups. Group I exhibited an increase in Plasma cortisol level, when compared to that of group II.