1Central Animal House, University of Agricultural Sciences, Bangalore-560 024, India.
2Department of Veterinary Physiology, Veterinary College, KVAFSU, Hebbal, Bangalore-560 024.
3National Institute of Animal Nutrition and Physiology Adugodi, Bangalore.
4PGADMAS, Hebbal, Bangalore-560 024.
*Current Address: Dr. M. K. Vinuthan, Department of Molecular Reproduction and Development Genetics (MRDG), Indian Institute of Science. Bangalore-560 012.
Aqueous and methanol leaf extract of Murraya koenigii were investigated for hypolipidemic effects on male Sprague Dawley rats. The rats were divided into three groups of six animals each. The first group (I) received vehicle alone to serve as control. The second (II) and third (III) groups received aqueous extract (600 mg/kg b.w.) and methanol extract (200 mg/kg b.w.) respectively daily orally for a period of eight weeks. There were no significant changes in lipid profile in group I rats. In groups II and III plasma cholesterol, triglycerides and phospholipids levels were significantly decreased when compared to group I. The decrease in the lipid profile may be due to the constituents present in the leaf which are found to stimulate insulin secretion. The present study therefore suggests that these extracts exert hypolipidemic activities in treated rats.
