Emerging Trends in ODF Formulation

The review highlights the versatility of preparation methods, particularly the solvent-casting production process, and novel 3D printing techniques that bring inherent flexibility. Three-dimensional printing technology not only diversifies active compounds but also enables a multilayer approach, effectively segregating incompatible drugs. For local and/or systemic drug delivery, Oro-dispersible films (ODFs) are thin, flexible, mechanically robust polymeric films that dissolve or disintegrate quickly in the oral cavity. Numerous facets of ODFs and their potential as a drug delivery system are examined in this review. Recent developments are briefed, including the thorough investigation of formulation ingredients like polymers and plasticizers. In addition to allowing for a multilayer approach and diversifying active ingredients, three-dimensional printing technology efficiently separates incompatible medications. An important advancement that increases the effectiveness of oral drug administration and expands the range of medications that can be administered through this route is the use of nanoparticles into ODF formulations. This review offers a thorough overview of the changing field of Oro dispersible drug delivery by illuminating the many in vitro evaluation techniques used to describe ODFs, ongoing clinical trials, approved commercial goods, and recent patents. Present-day patient-centric strategies include creating ODFs with features that are more patient-friendly, like better taste masking, simpler administration, and increased patient compliance, as well as tailoring ODF formulations to each patient’s requirements. For quick advancement in the developing field of Oro-dispersible drug administration, it is essential to investigate new functional excipients that may improve the penetration of oligonucleotides, fragile proteins, and high-molecular-weight polar pharmaceuticals.