Divine College of Pharmacy, Department of Pharmaceutical Quality Assurance, Satana
*Corresponding Author E-mail: mayurbhamare0404@gmail.com
The superfamily of heme-containing proteins known as cytochrome P450 (CYP) enzymes is essential to the metabolism of many different endogenous and exogenous substances, including medications. Individual differences in CYP enzyme activity have a substantial impact on medication safety and efficacy, which can result in adverse drug reactions (ADRs) and drug-drug interactions (DDIs). The structure, function, and control of CYP enzymes, their involvement in drug metabolism, the mechanisms behind DDIs, and the clinical consequences for pharmacotherapy are all thoroughly examined in this study. It also covers methods for anticipating and controlling DDIs in order to maximise therapeutic results.
Drug Metabolism, Enzyme induction, Enzyme inhibition, CYP isoforms, Pharmacokinetics, CYP450 substrates, CYP450 inhibitors, Drug Interaction
