Degradation Study of Spironolactone by UV-Visible Spectrophotometry Method in Bulk Form

Spironolactone is most commonly used anti-diuretic agent in clinical practices. Spironolactone site of action is intracellular aldosterone receptors in the distal tubule cells. This increases the excretion of water and sodium and decreases the excretion of potassium. The degradation is most commonly found problem in most of products. The ICH guidelines states the parameters for forced degradation studies which includes the Acid/base stress testing, heat or humidity, photo degradation, pH variation. official assay limilight for 30 min the drug shows extremely decreased availability.