Spray Drying: A Promising Technique to Enhance Solubility

Poor solubility and bioavailability of an existing or newly synthesized drug always pose challenge in the development of efficient pharmaceutical formulation. Numerous technologies can be used to improve the solubility and spray drying technology can be successfully useful for development of product from lab scale to commercial scale with a wide range of powder characteristics. Spray drying is an interesting manufacturing technique for the pharmaceutical industry since it uses a one-step process for formation and drying of powders. Using this technique the number of unit operations is reduced, improving production efficiency and reducing costs. Since spray drying is a technique which can be easily automated and equipped for in-line product analysis. Current review deals with the importance of spray drying technology in drug delivery, basically for solubility and bioavailability enhancement, instrumentation, advantages and the various applications of spray drying. Overall, spray drying has a bright future due to its versatility, effciency and the driving force of poorly soluble drugs.