Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Trivandrum
*Corresponding Author E-mail: merlinbinu76@yahoo.co.in
Online published on 24 October, 2018.
Toxicokinetics (TK) is ‘the generation of pharmacokinetic data, either as an integral component in the conduct of non-clinical toxicity studies or in specially designed supportive studies, to assess systemic exposure. Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals. Toxicokinetics, toxicodynamics and toxicogenomics (TK/TD/TG) methods are the potential tools in human health risk assessment.
Toxicokinetics, PBTK model, PBPK model, safety assessment, Drug development
