In-Vitro Evaluation of Different Marketed Brands of Paracetamol Tablets Using Quality Control Tests

A lot of suppliers sale the paracetamol tablets as the OTC product among the patients, as a mostly use antipyretic and analgesic agent. Ultimate aim of this research was to compare and evaluate different brands of paracetamol tablets for their performance which are sold in sangli district. Five different brands of the acetaminophen tablets (paracetamol tablets) were randomly collected from the different pharmacy shops present in the sangli district. To perform this experimental work various official books like USP and BP was used to determine the in vitro quality tests using various procedure as well as different analytical tests. In evaluation of different brands of paracetamol tablets we were perform determination of different parameters like weight variation, friability, hardness, drug content, identification test, disintegration time and dissolution profile. By performing weight variation and friability test we were fond that different brands show acceptable value. From UV analysis of different sample we were found that none of the brand contain NLT 95% of active drug content. Each and every branded tablet taken for comparative evaluation gives different results from each other but no one crosses the limits given in official books.