A Review on Sintering Method in Pharmaceutical Sciences

In the pharmaceutical field, sintering has been described as the mechanism for the strengthening of the mechanical properties of consolidated pharmaceutical powders at elevated temperatures, for solid-bond formation during tablet compression, and for the thermal curing of polymer-latex film coatings. The sintering process has been used for the fabrication of controlled-release matrix tablets and for the stabilization of the drug permeability of film coatings derived from various pharmaceutical lattices. The concept of sintering was applied in the investigation of the effect of heating on the mechanical properties of the pharmaceutical powders. The formation of solid bonds within powder bed during tablet compression was also studied in terms of sintering. The changes in the hardness and disintegration time of tablets stored at elevated temperatures were described as result of sintering.