Floating Drug Delivery: A Novel Approach

Recent years have seen scientific and technological advancements in the investigation and development of novel drug delivery systems by addressing physiological problems such short stomach residency periods and irregular gastric emptying timings. Some of the techniques being used to increase the stomach residency times include polymeric bioadhesive systems, floating drug delivery systems, swelling and expanding systems, changed-shape systems, high-density systems, and other delayed gastric emptying devices. The most recent developments in FDDS technology, including commercially available goods and patented delivery methods, are discussed in this study along with their advantages and potential applications in oral controlled drug administration in the future. The stomach's ability to absorb medications may be enhanced by prolonged GRT. Some of the techniques currently employed to extend the GRT include modified-shape systems, high-density systems, polymeric bioadhesive systems, swelling and expanding systems, floating drug delivery systems (FDDS), and various delayed gastric emptying devices. In vivo absorption qualities are improved by drugs manufactured in these systems that have a limited absorption window. Furthermore, local medication delivery to the stomach and proximal small intestine would be facilitated by gastroretention. As a result, gastroretention might help expand access to new products, which would improve treatment effectiveness and offer patients major benefits. Examining the most recent studies and technical developments in the development of gastroretentive dosage forms is the goal of this presentation.