Asian Journal of Pharmacy and Technology
  • Year: 2025
  • Volume: 15
  • Issue: 3

Effectiveness of Alpha Lipoic Acid in Type 2 Diabetes Mellitus patients with Cardiac Autonomic Neuropathy

  • Author:
  • P Geetha1,*, D Bharathi1, N Deepa1, G Gopi1, Shamshath Begum1, T Devi2
  • Total Page Count: 3
  • Published Online: Nov 18, 2025
  • Page Number: 286 to 288

1Faculty of Pharmacy, Sree Balaji Medical Collage and Hospital Campus, BIHER, Chromepet, Chennai

2Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Kelambakkam, Chennai

*Corresponding Author E-mail: lgeethapharma@gmail.com

Online Published on 18 November, 2025.

Abstract

One of the major side effects of diabetes mellitus (DM) that raises the rates of morbidity and death is diabetic cardiovascular autonomic neuropathy (CAN). As an antioxidant, alpha lipoic acid shows promise in lowering autonomic neuropathy. 138 participants with type 2 DM participated in the prospective observational research. Autonomic function, biochemical markers, and baseline demographics were measured. Patients receiving anti-diabetic medicine and oral dose of 200 mg of alpha lipoic acid for complications were observed for three months. Prior to and following the three-month period, the autonomic nerve system index (ANS) score was assessed. The ANS index score significantly decreased, and the neuropathy was found to have improved. There was statistical significance in the results. The study’s conclusions demonstrated alpha lipoic acid’s possible advantages in CAN management.

Keywords

Cardiovascular Autonomic Neuropathy, Alpha-Lipoic Acid, Diabetes