1Gautam College of Pharmacy, Hamirpur, Distt. Hamirpur, H.P, India
2Abhilashi College of Pharmacy, Nerchowk, Distt. Mandi, H.P, India
3Gautam College of Pharmacy, Hamirpur, Distt. Hamirpur, H.P, India
4Gautam College of Pharmacy, Hamirpur, Distt. Hamirpur, H.P, India
5Minerva College of Pharmacy, Indora, H.P, India
6Shiva Institute of Pharmacy, Chandpur, Distt. Bilaspur, H.P, India
*Corresponding Author E-mail: vikrantdalwal692@gmail.com
Online Published on 23 May, 2025.
Four quinoline derivatives are synthesized by reflux reaction of isatin with beta keto ester. The studies of docking results show good hydrogen bonding using Molegro virtual docker software (MVD). Mentioned compounds exhibit Mol dock score between the range -78.3595 to -124.166 more as compare with standard ligand chloramphenicol i.e., -99.4262. Synthesized compounds were then characterized by 1H- NMR and FTIR and tested in-vitro. The synthesized compounds show good antibacterial activity against bacteria (E. coli, Staphylococcus aureus, S. typhi, B. subtilis).
Quinoline-4- Carboxylic Acid, Docking, Antibacterial, Isatin, Molegro Virtual Docker
