Novel approach and current application of bilayer tablet - A review

The drug product life cycle is extended and novel drug delivery systems, such as chewing devices, buccal or mucoadhesive delivery systems and floating tablets, gastro-retentive delivery, are created to administer fixed dose combinations of various active pharmaceutical ingredients (APIs). Bilayer tablets have made it possible to develop controlled-drug delivery systems with predetermined release patterns or slow-release and immediate-release layers. In addition, bilayer tablets were subjected to in vitro drug release studies in simulated gastric and intestinal fluids to assess their ability in providing the desired controlled drug delivery.