Fabrication and evaluation of cefpodoxime proxetil niosomes

The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.