Formulation and Evaluation of Glipizide Effervescent Tablets

The current study aims to create effervescent tablets of Glipizide that offer better elegance, comfort, and improved drug performance in treating diabetes compared to traditional tablets. Three versions of the effervescent Glipizide tablets (5mg each) were made using different combinations of ingredients. Using the wet granulation method, 60 tablets were made for each version, each weighing 700mg. The physical properties of both the granules and tablets were tested using established methods. Tests like angle of repose, Hausner ratio, Carr's index, loss on drying, and moisture content showed that the granules had good flow and compressibility. However, tests related to physical appearance and drug content did not clearly show which of the three tablet versions the best was. The friability of the tablets was 0. 71%, which is within the acceptable range set by USP? The average time it took for the tablets to break down was between 95 and 105 seconds. The potency test showed that F1 had 95%, F2 had 88%, and F3 had 97% of the expected drug content. The drug release followed a straight line over time. After 1.5hours, F3 released the highest amount of the drug, at 59%, showing better solubility. Since Glipizide is a drug that dissolves poorly in water, the effervescent tablet may help with the breakdown and release of the drug, leading to better absorption in the body.